National University of Singapore

Impactful Discoveries
in Cardiac Genomics
& Precision Medicine

We study the molecular mechanisms underlying heart failure — from single-cell transcriptomics and cardiac epigenomics to iPSC models and population-scale prevention — bridging basic science with clinical impact across Southeast Asia.

2013
Lab established in Singapore
45+
Team members
4
Research themes
2 sites
NUS CVRI · A*STAR GIS
Cardiomyocyte imaging · Foo Lab, NUS
Cardiomyocyte imaging · Foo Lab, NUS
Affiliated with
National University of Singapore
NUS Cardiovascular Research Institute
Genome Institute of Singapore, A*STAR
National University Heart Centre

Professor Roger Foo

Roger trained with the late Professor David de Bono (British Heart Foundation Chair of Cardiology, Leicester) before moving to Cambridge, where he worked under Professor Morris Brown MD, FRCP, FMedSci, FRS at the Clinical Pharmacology Unit.

Awarded a Wellcome Trust Fellowship, Roger joined Professor Rick Kitsis at Albert Einstein College of Medicine, NYC, exploring the molecular regulation of heart failure and cardiomyocyte apoptosis. He returned to Cambridge in 2006 to start Foo Lab 1.0 at the Division of Cardiovascular Medicine, funded by the British Heart Foundation and Wellcome Trust.

Foo Lab 2.0 was established in Singapore in 2013, expanding into genomics, transcriptomics, and population health. Roger holds several leadership roles at NUS, founded the NUHS Clinician Scientist Academy, and serves as chair of the MOH Clinician Scientist Residency Research Panel and President of the College of Clinician Scientists, Academy of Medicine Singapore.

"Our mission is to make impactful scientific discoveries through world-class research — and to train the next generation of scientists who will change how we understand the heart."

Professor Roger Foo

Research Themes

Research Overview →
Transcriptomics — Circular genome map
Transcriptomics

Non-coding RNAs & Gene Therapy

We use single-cell and spatial RNA sequencing to identify cardiomyocyte subpopulations, characterise circular and long non-coding RNAs, and develop AAV-based gene therapy strategies for heart failure.

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Epigenomics — MEF2A motif
Epigenomics

Cardiac Epigenomics & Genetic Variation

We have mapped the global cardiac enhancer–promoter landscape and characterised genetic variants influencing disease risk through cis-regulatory activity — with a particular focus on Southeast Asian populations.

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Stem Cells — fluorescent cell microscopy
Stem Cells

hESCs & iPSC Disease Modelling

Using human embryonic and induced pluripotent stem cells, we model cardiac disease in vitro to probe cell-state transitions and test therapeutic interventions at single-cell resolution.

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Clinical Research — 3D printed heart model
Clinical Research

Cardiometabolic Disease & Prevention

Closer to the patient — we combine clinical samples, population health data, and CRISPR-based functional genomics to tackle the looming cardiometabolic crisis across Southeast Asia.

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Project RESET

Project RESET (Reducing Excess risk in Singapore through Enhanced Treatment) is a population-level clinical study aimed at preventing heart disease in Singapore. Working alongside primary care, community health, and national health bodies, we are identifying and intervening in high-risk individuals across Queenstown and beyond.

RESET brings together genomics, digital health, and community outreach in a concerted drive to reduce cardiovascular burden across Southeast Asia.

10k+
Participants enrolled
SEA
Regional focus
GP
Primary care led
MOH
Nationally supported
Visit Project RESET →
Project RESET team

Lab Values

Complementarity Connectivity Creativity Caring Passion Respect Positivity Excellence Integrity

Meet the Team

Full Team →
Roger Foo
Roger Foo
Professor of Medicine
Matias Autio
Matias Autio
Senior Research Fellow
Matthew Ackers-Johnson
Matthew Ackers-Johnson
Assistant Professor
Rijan Gurung
Rijan Gurung
Research Fellow
Prasanna Vidyasekar
Prasanna Vidyasekar
Research Fellow
Mick Lee
Mick Lee
Research Fellow
Yike Zhu
Yike Zhu
Research Fellow
Beverly Wong
Beverly Wong
RESET Project Manager

News & Updates

All News →
RESET Townhall
Events · Aug 2025

Reset TOWNHALL — Project RESET's Inaugural Community Event

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FDX1 Nature Cardiovascular Research
Publication · 2025

Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism

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Asian Focus Global Impact
Media · 2025

Asian Focus, Global Impact: Understanding Heart Disease in the Asian Context

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Peer-reviewed Research

Our work spans high-impact journals in cardiovascular medicine, genomics, and precision health. Browse the full publication record via NUS Discovery or GitHub.

View Publications GitHub →
Nature Cardiovascular Research Circulation Nature Communications Cell Reports JACC